A new review of glutathione supplements has named mindbodygreen’s ultimate multivitamin+ as the best overall option for 2026. The product contains 100 milligrams of Setria glutathione, a clinically studied form of the antioxidant.
Glutathione is a compound made from three amino acids: glutamine, glycine, and cysteine. It is found in nearly every cell in the body, with high concentrations in the liver. Its main role is to neutralize free radicals, support the body’s natural detoxification processes, and help regenerate other antioxidants such as vitamins C and E.
The body produces glutathione on its own, but production declines with age. Factors like poor sleep, chronic stress, alcohol use, environmental toxins, intense exercise, and nutrient deficiencies can increase the body’s need for this antioxidant.
Research suggests that maintaining healthy glutathione levels may help protect cells from oxidative stress, support liver function, aid immune system health, and promote healthy aging by protecting mitochondria.
When choosing a glutathione supplement, experts recommend looking for forms with clinical research supporting their absorption, such as Setria glutathione. Other features to consider include third-party testing for quality, minimal additives, and added nutrients like vitamin C or selenium that support glutathione’s activity.
People who may benefit from a glutathione supplement include adults looking to support healthy aging, those exposed to environmental pollutants or oxidative stress, people who regularly consume alcohol, athletes recovering from intense exercise, and anyone seeking to support liver function and antioxidant defenses.
The review also highlighted several other products. Codeage Liposomal Glutathione was named best high-dose option, delivering 1,000 milligrams of liposomal glutathione with NSF certification. Thorne Glutathione-SR was selected as best sustained-release, offering 175 milligrams with a technology designed for gradual delivery. Quicksilver Scientific Liposomal Glutathione was named best liquid formula, available in cacao mint or lemon mint flavors. Cymbiotika Liposomal Glutathione was recognized as best with CoQ10, providing N-acetyl-L-cysteine and other glutathione precursors in a liposomal delivery system.
The mindbodygreen product was praised for combining 100 milligrams of Setria glutathione with 33 other vitamins, minerals, and phytonutrients. The formula also includes resveratrol, lycopene, lutein, zeaxanthin, and black pepper extract, along with selenium and vitamin C. The review noted that this combination makes it suitable for supporting healthy aging, cellular health, immune function, and overall wellness with a single daily supplement.
